Newswire (Published: Monday, September 14, 2020, Received: Monday, September 14, 2020, 4:14:44 PM CDT)

Word Count: 519

2020 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Investigators publish new report on Oncology - Prostate Cancer. According to news reporting from Honolulu, Hawaii, by NewsRx journalists, research stated, “It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N=1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls).”

Financial supporters for this research include NIH S10 Shared Instrumentation Grant, University of Hawaii Cancer Center Seed Grant, Department of Education of Fujian Province, P R China.

The news correspondents obtained a quote from the research from the University of Hawaii Manoa, “We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes. Genome wide association studies have identified multiple loci associated with risk of developing prostate cancer but the functional significance of many of these are unknown.”

According to the news reporters, the research concluded: “Here, after generating models to predict methylation, the authors identify CpG methylation sites associated with prostate cancer.”

For more information on this research see: An Integrative Multi-omics Analysis To Identify Candidate Dna Methylation Biomarkers Related To Prostate Cancer Risk. Nature Communications, 2020;11(1):. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - http://www.nature.com/; Nature Communications - http://www.nature.com/ncomms/)

Our news journalists report that additional information may be obtained by contacting Lang Wu, University of Hawaii Manoa, Canc Epidemiol Div, Populat Sci Pacific Program Univ, University of Hawaii, Cancer Center, Honolulu, HI 96822, United States. Additional authors for this research include Yanfa Sun, Jingjing Zhu, Yaohua Yang, Xingyi Guo, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Wei Zheng, Bingshan Li, Ran Tao, Chong Wu, Jason B. Nikas, Monique J. Roobol, Graham G. Giles, Hermann Brenner, Esther M. John, Judith Clements, Eli Marie Grindedal, Jong Y. Park, Janet L. Stanford, Zsofia Kote-Jarai, Rosalind A. Eeles and Christopher A. Haiman.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41467-020-17673-9. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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