Newswire (Published: Tuesday, May 14, 2019, Received: Tuesday, May 14, 2019, 4:01:58 PM CDT)

Word Count: 419

2019 MAY 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Investigators publish new report on Oncology - Prostate Cancer. According to news reporting originating in Urbana, Illinois, by NewsRx journalists, research stated, “First-line therapy for advanced or metastatic prostate cancer (PCa) involves the removal of tumor-promoting androgens by androgen deprivation therapy (ADT), resulting in transient tumor regression. Recurrent disease is attributed to tumor adaptation to survive, despite lower circulating androgen concentrations, making the blockage of downstream androgen signaling a chemotherapeutic goal for PCa.”

Financial support for this research came from National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health.

The news reporters obtained a quote from the research from the University of Illinois, “Dietary intake of tomato and its predominant carotenoid, lycopene, reduce the risk for PCa, and preclinical studies have shown promising results that tomato and lycopene can inhibit androgen signaling in normal prostate tissue. The goal of this systematic review was to evaluate whether mechanistic evidence exists to support the hypothesis that tomato or lycopene interact with the androgen axis in PCa. Eighteen studies (n = 5 in vivo; n = 13 in vitro) were included in the final review. A formal meta-analysis was not feasible due to variability of the data; however, the overall estimated directions of effect for the compared studies were visually represented by albatross plots. All studies demonstrated either null or, more commonly, inhibitory effects of tomato or lycopene treatment on androgen-related outcomes.”

According to the news reporters, the research concluded: “Strong mechanistic evidence was unable to be ascertained, but tomato and lycopene treatment appears to down-regulate androgen metabolism and signaling in PCa.”

For more information on this research see: Can Lycopene Impact the Androgen Axis In Prostate Cancer?: a Systematic Review of Cell Culture and Animal Studies. NUTRIENTS, 2019;11(3):. NUTRIENTS can be contacted at: Mdpi, St Alban-Anlage 66, Ch-4052 Basel, Switzerland.

Our news correspondents report that additional information may be obtained by contacting J.W. Erdman, University of Illinois, Division of Nutritional Sciences, Urbana, IL 61801, United States. Additional authors for this research include C.C. Applegate and J.L. Rowles.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3390/nu11030633. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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