Newswire (Published: Monday, July 20, 2020, Received: Monday, July 20, 2020, 4:13:07 AM CDT)
Word Count: 451
A GENE that fuels the spread of prostate cancer has been discovered by scientists.
The protein makes tumours more aggressive, helping them migrate to other organs, according to research.
Experiments on human cells and mice found turning it off stopped the disease in its tracks, so opening the door to new treatments.
Lead author Dr
“What we can say is this finding applies to the patients we tested, who were followed up over a period of 10 years, as well as our mouse and in-vitro models.”
She added: “We are looking at what exactly this gene does, to see if we can find a way of regulating it in real-life cancers. Opening a way to controlling whether tumours risk spread would be a significant step towards controlling prostate cancer.”
Her team based the finding on 44 “high-risk” men with tumours likely to spread, or metastasise –19 of whose did.
A DNA analysis showed they had many more copies of the AZIN1 gene than the 25 others who were cured after treatment.
To test this the researchers changed its activity in cells grown in the lab and rodents genetically engineered to develop prostate cancer.
Reducing the activity, or expression, of the gene resulted in less spread.
“There are many different types and causes of prostate cancer, so this finding is still a long way from any clinical application.”
It is also believed AZIN1 plays a role in other cancers, offering hope of developing a drug for multiple forms including those of the breast, bowel and lung.
Latest figures show prostate cancer is now the most commonly diagnosed cancer in
In 2018 there were nearly 50,000 registered cases ,around 8,000 more than in 2017.
Celebrities such as actor
The findings were presented at an
One in 10 men north of the Border are likely to develop the disease.
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