Newswire (Published: Monday, March 4, 2019, Received: Monday, March 4, 2019, 5:36:46 PM CST)

Word Count: 456

2019 MAR 04 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- A new study on Oncology - Prostate Cancer is now available. According to news reporting originating from Rochester, Minnesota, by NewsRx correspondents, research stated, “The perineural spread of prostate cancer into pelvic peripheral nerves is a rare, but increasingly recognized, entity. This form of metastasis invades the lumbosacral plexus via the splanchnic nerves innervating the prostate.”

Our news editors obtained a quote from the research from Mayo Clinic, “The prevalence of perineural spread is likely underappreciated, and further imaging-based studies are needed to elucidate its true frequency. A retrospective review was performed using an institutional radiology database. Medical reports from patients with prostate cancer who had undergone positron emission tomography (PET) imaging were queried for terms suggestive of perineural spread. PET and magnetic resonance imaging (MRI) from the identified patients were blindly reviewed for peripheral nerve involvement by 2 nuclear medicine and 2 musculoskeletal radiologists. A total of 22 patients were identified. After review by the radiologists, 16 patients had positive findings of perineural spread found on PET and 15 had abnormalities found on MRI involving lumbosacral plexus neural elements. All patients with biopsy-proven neoplastic perineural spread (including 1 patient with malignant peripheral nerve sheath tumor) had positive findings on both PET and MRI. All patients with biopsy-proven inflammatory lesions had negative PET and variable MRI findings. The perineural spread of prostate cancer might be more common than previously thought. The use of multimodal imaging for patients suspected of having perineural spread should be a part of the treatment algorithm.”

According to the news editors, the research concluded: “Targeted fascicular biopsy might be indicated for patients with progressive neurological deficit and an unclear diagnosis.”

For more information on this research see: Multimodal Imaging Aids In the Diagnosis of Perineural Spread of Prostate Cancer. World Neurosurgery, 2019;122():E235-E240. World Neurosurgery can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; World Neurosurgery -

The news editors report that additional information may be obtained by contacting R.J. Spinner, Mayo Clinic, Dept. of Neurol Surg, Rochester, MN 55905, United States. Additional authors for this research include J.J. Stone, D.Z. Khan, D.A. Adamo, A.T. Packard, S.M. Broski, M.A. Nathan and B.M. Howe.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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