Newswire (Published: Thursday, April 4, 2019, Received: Thursday, April 4, 2019, 4:03:08 PM CDT)

Word Count: 392

2019 APR 04 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Investigators discuss new findings in Oncology - Prostate Cancer. According to news originating from Seattle, Washington, by NewsRx correspondents, research stated, “Reciprocal signaling between prostate stroma and its epithelium are fundamental to organ development and homeostasis. Similarly, interactions between tumor cells and stromal constituents are central to key aspects of carcinogenesis and malignancy growth involving tumor cell invasion, dissemination, and growth in distant sites.”

Funders for this research include National Institutes of Health, Prostate Cancer Foundation, Canadian Institutes of Health Research Postdoctoral Fellowship Program.

Our news journalists obtained a quote from the research from Fred Hutchinson Cancer Research Center, “The prostate stroma is complex with several distinct resident cell types, infiltrating nonresident cell types and an amalgam of structural matrix factors, matricellular proteins, metabolites, growth factors, and cytokines. Of importance, the stroma is dynamic with changes in composition as a cause or consequence of intrinsic and extrinsic factors. In the context of epithelial neoplasia, the prostate stroma undergoes phenotypic changes with a loss of well-differentiated smooth muscle cell population and the expansion of cancer-associated fibroblast populations. This reactive stroma further coevolves with tumor progression.”

According to the news editors, the research concluded: “Recent studies show the role of tumor microenvironment components in therapy resistance and highlight the importance of a thorough knowledge of cross talk between tumor cells and microenvironment niches to develop new therapeutic strategies.”

For more information on this research see: Cellular Constituents of the Prostate Stroma: Key Contributors To Prostate Cancer Progression and Therapy Resistance. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2018;8(8):. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE can be contacted at: Cold Spring Harbor Lab Press, Publications Dept, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA.

The news correspondents report that additional information may be obtained from P.S. Nelson, Fred Hutchinson Canc Res Ctr, Div Human Biol & Clin Res, Seattle, WA 98109, United States.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1101/cshperspect.a030510. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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