Newswire (Published: Wednesday, November 13, 2019, Received: Wednesday, November 13, 2019, 5:28:14 PM CST)

Word Count: 522

2019 NOV 13 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Medical Devices Daily -- Fresh data on Surgery - Prostatectomy are presented in a new report. According to news reporting originating from Chengdu, People’s Republic of China, by NewsRx correspondents, research stated, “To investigate potential preoperative predictors of urethral or apical positive surgical margin (PSM) and the value of apical prostate biopsy in predicting urethral/apical margin status after radical prostatectomy (RP). A total of 531 patients who underwent RP during 2010 to 2017 at West China Hospital were enrolled in this retrospective study.”

Our news editors obtained a quote from the research from Sichuan University, “Preoperative and postoperative factors including age, BMI, PSA, clinical T stage and biopsy Gleason score were analyzed. Univariate analysis and logistic regression were used to find out the potential predictive factors for PSM. Two logistic regression models were built to evaluate the role of apical prostate biopsy in predicting urethral/apical margin status. The overall PSM rate was about 30.1% (160/531) and 97 of them were reported urethral/apical PSM. The incidence of urethral or apical PSM in patients with positive cores in the apical prostate was higher than those without (23.0% vs 9.9%, p<.001). We further found that the multivariable model with positive apical prostate biopsy could significantly increase the predictive value of urethral or apical PSM status (AUC: 0.744 vs 0.783, p=.016). Our analysis also showed that neo-adjuvant hormone therapy was an independent protective factor for urethral or apical PSM in patients with positive apical prostate biopsy, but not all patients. This study revealed the necessity of apical prostate biopsy to predict the risk of apical or urethral PSM.”

According to the news editors, the research concluded: “In clinical practice, neo-adjuvant hormone therapy should be given when patients with positive apical prostate biopsy to reduce the presence of PSM, especially patients with high/very high risk prostate cancer.”

For more information on this research see: The value of transperineal apical prostate biopsy in predicting urethral/apical margin status after radical prostatectomy. Medicine, 2019;98(43):e17633. Medicine can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Elsevier - www.elsevier.com; Medicine - http://www.journals.elsevier.com/medicine/)

The news editors report that additional information may be obtained by contacting J. Dai, Dept. of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, People’s Republic of China. Additional authors for this research include X. Zhang, J. Zhao, G. Sun, J. Chen, J. Liu, R. Tao, H. Zeng and P. Shen.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1097/md.0000000000017633. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Medicine is: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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Sichuan University
Lippincott Williams & Wilkins
Wolters Kluwer N.V.
Wolters Kluwer N.V.
Wolters Kluwer N.V.

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Eastern Asia
North America
People's Republic of China
United States
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Subjects

Science and Technology
      Scientific Research
Health and Wellness
      Medical Conditions and Diseases
            Cancer
                  Prostate Cancer
            Men's Health Issues
                  Prostate Cancer
            Urological Diseases
      Medical Specialties and Practices
            Surgery
            Urology
      Treatments and Therapies
            Surgery