Newswire (Published: Monday, February 18, 2019, Received: Tuesday, February 19, 2019, 5:57:46 PM CST)

Word Count: 404

2019 FEB 18 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Current study results on Oncology - Prostate Cancer have been published. According to news reporting from Ann Arbor, Michigan, by NewsRx journalists, research stated, “Rates of progression and treatment response in advanced prostate cancer are highly variable, necessitating non-invasive methods to assess the molecular characteristics of these tumors in real time. The unique potential of circulating tumor cells (CTCs) to serve as a clinically useful liquid biomarker is due to their ability to inform via both enumeration and RNA expression.”

Financial supporters for this research include National Institutes of Health, U.S. Department of Defense, Prostate Cancer Foundation, A. Alfred Taubman Medical Research Institute, National Science Foundation.

The news correspondents obtained a quote from the research from the University of Michigan, “A microfluidic graphene oxide-based device (GO Chip) is used to isolate CTCs and CTC clusters from the whole blood of 41 men with metastatic castration-resistant prostate cancer. Additionally, the expression of 96 genes of interest is determined by RT-qPCR. Multivariate analyses are conducted to determine the genes most closely associated with overall survival, PSA progression, and radioclinical progression.”

According to the news reporters, the research concluded: “A preliminary signature, comprising high expression of stemness genes and low expression of epithelial and mesenchymal genes, potentially implicates an undifferentiated CTC phenotype as a marker of poor prognosis in this setting.”

For more information on this research see: Detection of CTC Clusters and a Dedifferentiated RNA-Expression Survival Signature in Prostate Cancer. Advanced Science, 2019;6(2):1801254. Advanced Science can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (American Scientific Publishers - http://www.aspbs.com/)

Our news journalists report that additional information may be obtained by contacting S. Nagrath, University of Michigan, Dept. of Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109, United States. Additional authors for this research include M. Kozminsky, S. Fouladdel, E. Azizi, J.S. Chung, Y. Wang, T. Morgan, D.C. Smith and A. Alva.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1002/advs.201801254. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

Companies

National Institutes of Health
US Department of Defense
National Science Foundation
University of Michigan

Places

North America
United States
Americas
Michigan
Ann Arbor

Subjects

Science and Technology
      Scientific Research
            Medical Research
Health and Wellness
      Medical Conditions and Diseases
            Cancer
                  Prostate Cancer
            Men's Health Issues
                  Prostate Cancer
      Health Sciences
            Medical Research
Politics and Government
      Government Agencies (U.S.)
            Department of Defense
            Department of Health and Human Services
                  National Institutes of Health
            National Science Foundation