Newswire (Published: Friday, January 17, 2020, Received: Friday, January 17, 2020, 6:53:03 PM CST)

Word Count: 588

2020 JAN 17 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Investigators discuss new findings in Oncology - Prostate Cancer. According to news reporting originating from Houston, Texas, by NewsRx correspondents, research stated, “Effectively detecting and culturing circulating tumor cells (CTCs), is critical for diagnosis of early metastasis, monitoring anti-cancer therapeutic efficacy, and drug screening. However, most current FDA approved CTC detection methods are based on antibody binding, which has limitations due to the nature of variations in antibody preparation and antibody-CTC size mismatches.”

Funders for this research include I.I Rabi Scholars award, Columbia College, Dean’s award of Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA, Cecil M. Crigler MD Chair fund, Division of Urology, University of Texas Health Science Center-McGovern Medical School at Houston, Department of Surgery, Houston, TX, USA.

Our news editors obtained a quote from the research from the University of Texas M.D. Anderson Cancer Center, “Thus, searching for alternative and advanced methods is urgent and necessary. Prostate cancer tissue was digested by collagenase and cultured. Cancer stromal cells were identified and labelled with 4’,6-diamidino-2-phenylindole (DAPI) before incubation with whole blood of cancer mice (bearing a later stage of prostate cancer). The attached blood CTCs on the DAPI-labeled cancer stromal cells were detected, isolated, cultured and produced into individual cancer cell lines. Five clones of prostate cancer cells isolated from cancer tissue were successfully cultured. One (Clone-1) of the five clones showed positive staining for all three cancer stromal cell markers (CD133, alpha 2 beta 1 integrin and CD44). Clone-1 cells rich with epithelial cell adhesion molecule (EpCAM) on the cell surface were further identified. The Clone-1 stromal cells labeled as ‘bait’ attracted and caught a trace number of CTCs from the whole blood of mice with advanced stage cancer. Efficient culturing of the caught CTCs from single cell to forming of individual cancer cell line(s) were established. We present a fundamental advancement of CTC detection and culturing using a different mechanism ( cell-cell interaction) rather than the traditional antibody-based immune-binding, such as CellSearch ™ system. This study has potential to be fully developed into a novel approach for early cancer metastasis detection, and chemotherapy efficacy monitoring.”

According to the news editors, the research concluded: “The efficiently cultured CTCs could be used for single-clone CTC analysis and anti-cancer drug screening to further advance the development of individualized medicine.”

For more information on this research see: Novel Method To Detect, Isolate, and Culture Prostate Culturing Circulating Tumor Cells. Translational Andrology and Urology, 2019;8(6):686-695. Translational Andrology and Urology can be contacted at: Ame Publ Co, Flat-Rm C 16F, Kings Wing Plaza 1, No 3 Kwan St, Shatin, Hong Kong 00000, Peoples R China.

The news editors report that additional information may be obtained by contacting R. Wang, M.D. Anderson Cancer Center, University of Texas Health Science Center at Houston., Dept. of Surgery, Division of Urology, McGovern Med Sch & Houston, 6431 Fannin, Suite 6-018, Houston, TX 77030, United States. Additional authors for this research include D.N. Ru, S.P. So and B. King.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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