Newswire (Published: Thursday, June 27, 2019, Received: Thursday, June 27, 2019, 5:41:12 PM CDT)

Word Count: 351

2019 JUN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Data detailed on Oncology - Prostate Cancer have been presented. According to news reporting originating from Winston Salem, United States, by NewsRx correspondents, research stated, “More than 80% of patients with advanced prostate cancer (PCa) experience bone metastasis, which negatively impacts overall survival and patient quality of life. Various mouse models have been used to study the mechanisms of bone metastasis over the years; however, there is currently no model that fully recapitulates what happens in humans because bone metastasis rarely occurs in spontaneous PCa mouse models.”

Our news editors obtained a quote from the research from Wake Forest University, “Nevertheless, animal models of bone metastasis using several different tumor inoculation routes have been developed to help study bone metastatic progression, which occurs particularly in late-stage PCa patients. This chapter describes the protocols commonly used to develop models of bone metastatic cancer in mice using different percutaneous injection methods (Intracardiac and Intraosseous). These models are useful for understanding the molecular mechanisms of bone metastatic progression, including tumor tissue tropism and tumor growth within the bone marrow microenvironment.”

According to the news editors, the research concluded: “Better understanding of the mechanisms involved in these processes will clearly lead to the development of new therapeutic strategies for PCa patients with bone metastases.”

For more information on this research see: Models of Prostate Cancer Bone Metastasis. Methods in Molecular Biology, 2019;1914():295-308.

The news editors report that additional information may be obtained by contacting Y. Shiozawa, Dept. of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University, Winston-Salem, NC, United States. Additional authors for this research include M.R. Eber and Y. Shiozawa.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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