Newswire (Published: Tuesday, May 19, 2020, Received: Tuesday, May 19, 2020, 3:44:22 PM CDT)

Word Count: 566

2020 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Investigators publish new report on Oncology - Prostate Cancer. According to news originating from Urbana, Illinois, by NewsRx correspondents, research stated, “Dietary tomato products or lycopene protect against prostate carcinogenesis, but their impact on the emergence of castration-resistant prostate cancer (CRPC) is unknown. We hypothesized that tomato or lycopene products would reduce the emergence of CRPC.”

Funders for this research include National Institute of Food and Agriculture, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering.

Our news journalists obtained a quote from the research from the University of Illinois Urbana-Champaign, “Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were castrated at 12-13 wk and the emergence of CRPC was monitored by ultrasound in each study. In Study 1, TRAMP mice (n=80) were weaned onto an AIN-93G-based control diet (Con-L, n=28), a 10% tomato powder diet (TP-L, 10% lyophilized w/w, n=26), or a control diet followed by a tomato powder diet after castration (TP-Int1, n=26). In Study 2, TRAMP mice (n=85) were randomized onto a control diet with placebo beadlets (Con-Int, n=29), a tomato diet with placebo beadlets (TP-Int2, n=29), or a control diet with lycopene beadlets (Lyc-Int, n=27) following castration (aged 12 wk). Tumor incidence and growth were monitored by ultrasound beginning at an age of 10 wk. Mice were euthanized 4 wk after tumor detection or aged 30 wk if no tumor was detected. Tissue weights were compared by ANOVA followed by Dunnett’s test. Tumor volumes were compared using generalized linear mixed model regression. Ultrasound estimates for the in vivo tumor volume were strongly correlated with tumor weight at necropsy (R2=0.75 and 0.94, p<0.001 for both Studies 1 and 2, respectively). Dietary treatments after castration did not significantly impact cancer incidence, time to tumor detection, or final tumor weight. In contrast to studies of de novo carcinogenesis in multiple preclinical models, tomato components had no significant impact on the emergence of CRPC in the TRAMP model.”

According to the news editors, the research concluded: “It is possible that specific mutant subclones of prostate cancer may continue to show some antiproliferative response to tomato components, but further studies are needed to confirm this.”

For more information on this research see: Dietary Tomato or Lycopene Do Not Reduce Castration-Resistant Prostate Cancer Progression in a Murine Model. The Journal of Nutrition, 2020;():. The Journal of Nutrition can be contacted at: Amer Inst Nutrition, 9650 Rockville Pike, Bethesda, MD 20814, USA.

The news correspondents report that additional information may be obtained from J.W. Smith, Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. Additional authors for this research include J.L. Rowles, C.C. Applegate, R.J. Miller, M.A. Wallig, A. Kaur, J.N. Sarol, S. Musaad, S.K. Clinton, W.D. O’Brien and J.W Erdman.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1093/jn/nxaa107. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher’s contact information for the The Journal of Nutrition is: Amer Inst Nutrition, 9650 Rockville Pike, Bethesda, MD 20814, USA.

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